Again, we can construct isothermal planes showing the phases present in any part of the system at any temperature of interest. Pseudo ternary phase diagramthe gray area indicates the microemulsion region. The single phase boundary line is found on any section that. An equilibrium phase diagram gives the phases present at different values of thermodynamic intensive variables e. Phase diagrams for materials with more than two components are complex and difficult to represent. Phase diagrams and pseudosections ternary phase diagrams. The purpose of this research was to develop the pseudoternary phase diagrams for a. Gibbs phase diagrams can be used to show the influence of changes in the volume fractions of the different phases on the phase. We will limit our discussion of phase diagrams of multicomponent systems to binary alloys and will assume pressure to be constant at one atmosphere. Each time a new component is added, another intensive variable must be held constant if the phase diagram is to be drawn in twodimensions.
Gel may be prepared by adding a gelling agent to the. Uses a simulation to show how ternary phase diagrams are interpreted. Slow titration with aqueous phase was done to each weight ratio of oil and smix and visual observation was carried out for transparent and easily flow able oil in water nano emulsion. Eskandar moghimipour, anayatollah salimi, fatemeh leis abstract purpose. This document last updated on 12feb2004 eens 212 petrology prof. Construction of pseudoternary phase diagram is an important tool for screening of selfdispersible formulation components and to assess the effect of different component on invitro performance of. The phase diagram is an e ective tool to determine vehicle compositions, providing stable particulate dispersions, such as. The influence of oil, international journal of pharmaceutics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. For example, in co 2 injection into an oil reservoir, co 2, c 1, and c 2 are often lumped into a single light pseudo component, while c 3 to c 6 form the. These substances constitute the components comprising the system and should not be confused with the various phases found within the system. The ternary phase diagram contains a lot of information on the phase behavior of the mixture of three components. As far as i know there is nothing called ternary phase however there are ternary phase diagrams for 3component systems. Ivermectinloaded stable microemulsions and microemulsion gels were successfully formulated based on the selected compositions from the phase diagrams. Pdf the purpose of this study is to give an insight into the significance of pseudoternary phase diagram construction and its evaluation, as an.
A hypothetical ternary phase space diagram made up of metals a, b, and. Ternary phase diagrams give the precise and accurate data of the various composite component systems and are utilized in several areas. It is used in physical chemistry, petrology, mineralogy, metallurgy, and other physical sciences to show the compositions of systems. Two types of phase diagrams are suitable for alloys composition which are binary and ternary phase diagrams. People expressing interest can email to receive a copy. Pseudo ternary phase diagram construction to investigate concentration range of components for the existing boundary of mes, pseudo ternary phase diagrams were constructed using the water titration method. Ternary systems are more frequently encountered in practice than binary systems. Isopleth through hypothetical ternary phase diagram at a constant. Ternary phase diagrams click on an image or the link in the caption, and a pdf file of the diagram will download to your computer. Microwave dielectric properties with compositions in different regions of the phase diagram have been analyzed.
Pseudoternary phase diagrams of water, oil and ssmix of various hlb values range of 9. Preparation and evaluation of tretinoin microemulsion. The ternary phase diagram of the mgndag system is rather incomplete berger. According to solidliquid equilibrium data, the phase diagrams of coal gasification wastewater were determined, analyzed in detail and compared with those of pure water. Ultrasonicator can finally be used so to achieve the desired size range for dispersed globules. Investigations into the formation and characterization of. Find all the books, read about the author, and more. To differentiate within the two phase region and single phase region in the ternary diagram, pressure and temperature must be fixed. To apply the basic concepts of phase diagrams to binary aluminium alloys.
The pseudo ternary phase diagrams were developed by the water titration method. In this study, the effect of several shortchain alcohols on pseudo ternary phase diagrams. Liquidliquid equilibria for pseudo ternary systems. The majority of microemulsions use oil and water as immiscible liquid pairs. There will be different envelopes binodal curves at different pressures and temperatures.
However, it also contains considerable information on the phase behavior on the three binary mixtures, a b, b c and a c that is implied by examining the edges of the diagram and the intersecting regions of phase equilibria. A system, how ever, also can consist of a single component, such as an element or compound. However, it constructs a microemulsion and lamellar phase in a phase diagram without cosurfactant only at a narrow range of composition. Study of pseudoternary phase diagram behaviour and the effect of several tweens and spans on palm oil esters characteristics. Research article development and evaluation of atazanavir. To extend the discussion to an outline of ternary phase diagrams, and to show how a socalled pseudo binary section can be applied with benefit to the almgsi system for alloys balanced in mg2si. Ternary phase diagram basics interactive simulation youtube. Aliquots of each surfactant and cosurfactant mixture s mix were mixed with the oil at ambient temperature. Pdf study of pseudoternary phase diagram behaviour and the. Read investigations into the formation and characterization of phospholipid microemulsions. The binary phase diagram is used for system of two. Also shown is the pseudobinary line also called the quasibinary line for the composition al mg2si. Pseudo ternary phase diagram is used to map the optimal composition range for three key excipients according to the resulting droplet size following selfemulsification, stability upon dilution and viscosity. It provides editing features for three components, as well as fraction and percentage display.
The temperature at which freezing begins is shaded in. The binary phase diagram is used for system of two components and its classifications. Some of the pdf files are animations they contain more than one page. This is a ternary diagram editing and plotting activex control. A microemulsion is considered to be a thermodynamically or kinetically stable liquid dispersion of an oil phase and a water particles or droplets, with a size range of 5 nm200 nm, and has very low oilwater the wavelength of visible light, microemulsions are transparent. Ternary phase diagrams in materials science 3rd edition. A phase diagram of the li 2 omgotio 2 ternary system was established in this article, based on earlier research results and our present work. Pseudo phase diagram and microwave dielectric properties. Ternary eutectic weak ternary peritectic strong ternary peritectic l.
It features a 1hour lecture video, and also presents the prerequisites, learning objectives, reading assignment, lecture slides, homework with solutions, and resources for further study. On the basis of the solubility studies of drug in oil, surfactants and cosurfactants were used for construction of phase diagram. Crystallization in ternary systems containing an incongruently melting compound. Effect of shortchain alcohols as cosurfactants on pseudo. Development of microemulsion based topical ivermectin. Ternary phase diagrams institute for advanced study.
Phase equilibria for the pseudoternary system nacl. This is for a single phase, three component system. If a cosurfactant is used, it may sometimes be represented at a fixed ratio to surfactant as a single component, and treated as a single pseudo component. Pdf liquidliquid equilibria for pseudoternary systems. In miscible gas injection, the advancing gas or injecting. Ternary phase diagrams are used to represent all possible mixtures of three. Phase diagram study for the pboznocaosio fe o system.
For any mixture, the total of surfactant, cosurfactant and oil concentrations always added to 100% 46. Pseudoternary phase diagrams of a drug delivery system. Pseudoternary diagrams have been misused, however, in describing the. It is the boundary line around that single phase region. The liquidus isotherms can be plotted on this diagram as would be the case for a normal ternary phase diagram. Usually have elements at the corners as the constituents, but can have compounds. Pseudo ternary phase diagram were develop using aqueous titration method. Phase diagrams were constructed in the presence of drug to obtain the optimum concentrations of oil, surfactant, and cosurfactant. Development of selfdispersible oral formulation, javed ahmad, saima amin, kanchan kohli. Pdf construction of pseudoternary phase diagram and its. Smedds form fine oilwater emulsions upon addition to an aqueous media undergentle agitation. Phase diagrams have been constructed for the case of one component diagrams for a pure material, and for two component systems diagrams drawn at constant pressure. The pseudo ternary phase diagrams were constructed based on these selected oils and combination of different surfactantcosurfactant at different ratios.
Pseudo ternary phase diagrams of a drug delivery system by ziheng wang a thesis presented to the university of waterloo in fulfillment of the thesis requirement for the degree of master of applied science in chemical engineering waterloo, ontario, canada, 2009. Ternary phase diagram an overview sciencedirect topics. It graphically depicts the ratios of the three variables as positions in an equilateral triangle. Preparation and evaluation of tretinoin microemulsion based on pseudo ternary phase diagram. For example, whilst the compositional path in a four component system can be. Some of the pdf files are animations they contain more than one page that can be shown in sequence to see changes as temperature or some other variable changes. In general, the optimized compositions of snedds can be determined by typical pseudo ternary phase diagrams constructed using oil, surfactantcosurfactant, and water. Bytriangle a free ternary diagram viewereditor, houston, texas.
Pseudo ternary phase diagrams of systems containing waterlecithinalcohol and oil. Writing, translating and drawing, links for palaeobotanists. Ternary phase diagram basics interactive simulation. A ternary phase diagram has the shape of a triangular prism with an equilateral triangle as a foundation which is used to describe a three component system. Zikmund, in honour of his 65th birthday algorithms for calculation of ternary phase diagrams using the socalled. Pseudo ternary phase diagrams of mixed surfactant and cosurfactant smix, oil, and water but without drug incorporation were plotted, and each of them represents a side of the triangle.
This page contains materials for the solid solutions class session on unary phase diagrams. Lecithin is a natural amphiphilic molecule, the microemulsions of which are often employed as a transdermal delivery medium of drugs and cosmetics. The relative amounts of these three components can be represented in a ternary phase diagram. Pseudophase equilibrium of light and heavy crude oils for. The pseudoternary phase diagrams were constructidentification of phases of various oil, surfactant cosurfactants and water system by ternary phase diagram haroon k. Pseudophase equilibrium of light and heavy crude oils for enhanced oil recovery. Construction of pseudoternary phase diagram and its evaluation.
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